Future work is needed to determine the anatomical origin of EndMT formation, to assess the ability of not only VSMCs but also ECs, macrophages, and monocytes to secrete TGF-β2 in the cell line, and to test the association of blood TGF-β2 levels with different degrees of atherosclerosis in both animal and human models. Here, TGFB2 is linked to atherosclerosis.