In line with this notion, NMNAT1 deletion has reduced the viability of the acute myeloid leukemia (AML) cell lines MOLM13 and OCI-AML2, which is not rescued through the supplementation of the NAD+ precursors NAM, NA, NR, or NMN (that conversely rescued the same cell lines from FK866) and repressed leukemia progression in two patient-derived xenograft models [94]. This evidence concerns the gene STAC3 and acute myeloid leukemia.