A recent study illustrated that the chromatin modifier and epigenetic regulator bromodomain-containing protein 4 (BRD4) plays an important role in controlling the NAPRT expression in hepatocellular carcinoma (HCC) cells since NAPRT levels were reduced in HCC cell lines upon treatment with the BRD4 inhibitor AZD5153 [78]. This evidence concerns the gene NAPRT and hepatocellular carcinoma.