NAPRT and cancer: In the first place, studies have shown that NAPRT-proficient tumors are highly reliant on NAPRT-mediated NAD+ biosynthesis, which has pro-oncogenic effects in terms of promoting protein synthesis, fostering energy production and mitochondrial OXPHOS, supporting DNA repair (especially in BRCA-deficient cancer cells), and modulating tumor cell responsiveness to DNA-damaging agents and NAMPT inhibitors [70].