MMP8 and arthritic joint disease: Genomic analysis revealed a reduction in caspase-11 gene expression in the neutrophils of MMP-8-deficient inflammatory arthritic mice [54], suggesting that the caspase-11 non-canonical inflammasome inhibits neutrophil migration to synovial tissues and induces neutrophil apoptosis in the tissues, thereby alleviating arthritis symptoms through functional cooperation with MMP-8.