IFNG and infection: Interestingly, when the splenocytes were stimulated with the UV-inactivated C. muridarum, the IFN-γ production in response to immunization with aiChlNP-74 and aiChlNP -81 correlated with the response in the mice infected with C. muridarum (natural infection), suggesting that these nanobodies may have some therapeutic activity (Figure 7a).