Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL), a member of a superfamily tumor necrosis factor (TNF), can induce apoptosis of different types of tumor cells; this is because TRAIL death receptors are highly expressed on the surface of oncotransformed cells, but are absent on normal cells [121,122,123]. The gene discussed is TNFSF10; the disease is neoplasm.