INS and Hypoglycemia: Additionally, even if compared to our previous investigations, we did not have to utilize glucose infusions to balance the extent of the induced hypoglycemia; the necessary, if lower, insulin dosages to induce a hypoglycemic clamp might have, in connection with the more attenuated hypoglycemic state, resulted in a different metabolic situation since insulin is known to suppress renal gluconeogenesis [52,53].