The decidua is rich in unique lineages of suppressive myeloid DC that can be found in circulation: tolerogenic dendritic cells (tmDC), first discovered in young children and found to be numerous in COVID-19-convalescent pregnant women, are defined by the expression of CD4, CD14, the immunoglobulin-like transcript (ILT)-4 with the canonical markers CD11c and CD11b [7,8] and ILT-4+, and HLA-G+ DC, named DC-10, which is very important in orchestrating the early interaction between maternal immunity and the trophoblast [9,10]. The gene discussed is CD4; the disease is COVID-19.