Following skin injury, however, perifollicular levels of BMP decline and keratinocyte-derived CCL2 initiate the chemotaxis and recruitment of both CX3CR1+CCR2+ and Ly6C+CCR2+ macrophages; these macrophages produce several cytokines including TGF-β [126,127,128,129]. The gene discussed is CCR2; the disease is neoplasm.