Parkinson’s disease (PD) is defined as an age-related, clinically evident Parkinsonism, and pathologically neurodegenerative disease with specific neuronal loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and norepinephrine (NE) neurons in the locus coeruleus (LC) that are rich in neuromelanin (NM), a decrease in NM, and formation of toxic misfolded oligomers of α-synuclein [1]. This evidence concerns the gene SNCA and Parkinson disease.