On the other hand, DPSCs—or EVs secreted from them—have been used in in vivo studies of induced arthritis in rodents and have been shown to be capable of reducing cartilage and bone tissue wear, the presence of TNF-α and IFN-γ, the production of metalloproteinases, and the differentiation of Th17 cells [178,179,180]. This evidence concerns the gene TNF and arthritic joint disease.