The administration of SHED in models of immune diseases, such as ovariectomy-induced osteoporosis [170], experimental autoimmune encephalitis [215], and induced arthritis [216], decreased the infiltration of T lymphocytes into tissues, the differentiation of Th1 and Th17 cells, and the presence of IFN-γ, TNF-α, IL-1β, and IL-4, which also induced the generation of Tregs. Here, TNF is linked to arthritic joint disease.