Given the high prevalence of macroprolactinemia among women with elevated PRL levels and the difference in the management of patients with macroprolactinemia compared to true monomeric hyperprolactinemia, all patients with persistently elevated PRL levels, especially asymptomatic patients, should be screened with tests appropriate for the diagnosis of macroprolactinemia [54,287,288,289]. Here, PRL is linked to hyperprolactinemia.