However, persistently high levels of PRL can lead to (secondary to GnRH inhibition) hypogonadotropic hypogonadism related to the suppression of both LH and FSH, as well as fertility problems that, in women, are most often a result of ovulation disorders, including the complete disappearance of ovulation [45]. Here, GNRH1 is linked to hypogonadotropic hypogonadism.