In a large study evaluating the next-generation sequencing (NGS) of tumor tissues of 1144 non-small cell lung cancer (NSCLC) patients, PIK3CA mutations were found in 3.7% of patients, with the highest mutations in squamous cell carcinoma (8.9%) and less common in adenocarcinoma (2.9%) [74]. Here, PIK3CA is linked to non-small cell lung carcinoma.