Two miRNAs, Homo sapiens (hsa)-miR-4488 and hsa-miR-1228-5p, were significantly upregulated in the ILD-MDA5 Ab+ subset, and bioinformatic analysis suggested that these miRNAs may contribute to DM pathogenesis through their target genes, which are involved in systemic inflammation through the NFKβ pathway [16]. The gene discussed is IFIH1; the disease is dermatomyositis.