A comparative analysis of plasma EVs from DM patients revealed that 51 exosomal miRNAs were significantly upregulated in DM patients with ILD who were also positive for MDA5 (DM-ILD-MDA5+), compared to DM patients without ILD who were negative for 16 different myositis-specific antibodies (DM-nonILD-MSA16-) [16]. This evidence concerns the gene IFIH1 and interstitial lung disease.