FOXE1 and hypothyroidism: These included SNPs in the FOXE1 locus, which have been reported to be significantly associated with the thyroid cancer risk: rs965513 (G>A), rs1867277 (G>A) and the polyalanine repeat region (rs71369530) [13,14,15], as well as rs7850258 (A>G), for which the G allele has been associated with an increased risk for cleft lip, cleft palate and hypothyroidism, while the A allele was associated with thyroid cancer [28].