In addition to underlying germline driver alterations, the somatic activation of MAPK-pathway-related oncogenes is likely required in thyroid cancer’s multistep development, as shown in familial thyroid cancer cases [53,54,55,56,57], particularly in a previous study from our group, in which we reported the identification of the BRAF p.Val600Glu in thyroid tumours from a family harbouring the rare germline FOXE1 p.Ala248Gly variant [16]. This evidence concerns the gene BRAF and thyroid tumor.