Notably, this patient presented a rare somatic missense BRAF variant (c.1406G>C, p.Gly469Ala) that was only present in the malignant struma ovarii tumour, being absent in the adjacent (benign) teratoma tissue and in its normal and hyperplastic eutopic thyroid tissues (Figure S1B; Table 1 and Table S4). This evidence concerns the gene BRAF and neoplasm.