The role of FOXE1 in thyroid precursor cells’ migration, during embryogenesis, and its involvement in thyroid dysgenesis, thyroid ectopy, cleft palate and thyroid tumour development, prompted us to analyse this gene in two Portuguese families (F1 and F2) with members diagnosed with MSO (F1), TC (F2) and CP (F2). The gene discussed is FOXE1; the disease is thyroid gland disorder.