SMN2 and proximal spinal muscular atrophy: Even more, the investigators evaluated the role of Phosphoglycerate kinase 1 (PGK1), a protein involved in ATP synthesis in the glycolytic process and found that overexpression or pharmacological induction of PGK1 also rescues motor axon abnormalities in smn-MO zebrafish larvae, indicating that these pathways are potential therapeutic targets for treating SMA disease [49].