Although it is well-known that obesity-related insulin resistance may be mitigated by shifting from a high-fat diet to a normo-caloric one [156], the supplementation of Citrus flavonoids such as MYR to the diet could be employed as a therapeutic tool against obesity, since it was demonstrated to favor the upregulation of SIRT3 expression in adipose tissue, improving mitochondrial metabolism in C57BL6/J mice [157]. The gene discussed is SIRT3; the disease is obesity due to melanocortin 4 receptor deficiency.