SESN2 and non-small cell lung carcinoma: Treatment of H1299 NSCLC cells with 50 μM CA caused a time-dependent increase in levels of sestrin-2 (12 h: 297.9 ± 70.0%, p < 0.05; 24 h: 446.1 ± 102.2%, p < 0.001; Figure 4A).