Leger found from muscles isolated from patients with amyotrophic lateral sclerosis that, despite increased levels of Atrogin-1 and reduced AKT phosphorylation, FOXO1 and FOXO3 expression and nuclear localization were unchanged, whereas in healthy people altering muscle mass affected FOXO1 expression and nuclear localization. The gene discussed is FOXO3; the disease is amyotrophic lateral sclerosis.