Among them, six proteins were up-regulated (BANF1, CRYZL1, PSG3, ACPP, ANO10 and ITIH2) in GDM, while seven were down-regulated (TREML2, EIF3M, GBP1, RANBP1, PTGES3, CARHSP1 and OTUB1) (Figure 4a). The gene discussed is RANBP1; the disease is gestational diabetes.