ECE2 and early-onset autosomal dominant Alzheimer disease: Apart from the targets of ECE2 retrieved from the interactome-directed analysis related to muscle contraction, Eckman et al. [70] suggested that this peptidase can be involved in the degradation of the peptide β-amyloid, whose accumulation and deposition can lead to the formation of amyloid plaques, a hallmark of Alzheimer disease.