CXCL8 and non-small cell lung carcinoma: To elucidate whether CAFs containing CD248 release IL‐8, which, in turn, promote cisplatin chemoresistance in NSCLC in vivo, we first combined 5 × 106 A549 and 5 × 106 CAFs cells infected with sh‐CON‐or sh‐CD248‐carrying lentiviruses, then we administered the aforementioned cells into BALB/c nude mice, and then injected 2 mg/kg cisplatin into the A549 + CAFs‐sh‐CD248 or A549 + CAFs‐sh‐CON mice.