Based on these functional investigations, CD248 modulated the nuclear factor kappa B (NF‐κB) axis to enhance the CAFs‐mediated release of IL‐8, which resulted in NSCLC cisplatin resistance, and additionally, activated NF‐κB and up‐regulated ATP‐binding cassette transporter B1 (ABCB1) expression. Here, ABCB1 is linked to non-small cell lung carcinoma.