Given that DAMPs are released from ferroptotic cells in a NINJ1-dependent manner, it will be very interesting to investigate the role of NINJ1 in diseases that have been shown to involve ferroptosis, such as acute renal failure caused by ischemia, nephrotoxic drugs or urinary tract obstruction, acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and intestinal bowel disease (IBD). The gene discussed is NINJ1; the disease is acute lung injury.