DUSP8 and colorectal cancer: Previous studies reported that miRNAs, which are a class of important gene post-transcriptional factors, may be involved in post-transcriptional regulation by binding to the 3′-untranslated region (3′-UTR) of DUSP8 and thereby inhibiting the suppressive effect of DUSP8 on colorectal cancer cell proliferation and migration [11] and MAPK inhibitor resistance [12, 13].