EZH2 and myelodysplastic syndrome: Ezh2 knockout mice (Ezh2−/−) developed myelodysplastic disorders characterized by anemia, splenomegaly, and dysplasia of the bone marrow, and the concurrent loss of both Tet2 and Ezh2 resulted in either an MDS phenotype (pancytopenia, myelodysplasia) or MDS/MPN phenotype (monocytosis, splenomegaly) [63].