To the best of our knowledge there are only a few studies using mathematical models and machine learning algorithms to predict clinical outcomes in other spinocerebellar ataxias including SCA1, SCA2, SCA3 and SCA6 (Tezenas du Montcel et al. 2014; Peng et al. 2021; Ru et al. 2022; Hatano et al. 2023). The gene discussed is ATXN3; the disease is cerebellar ataxia.