In conclusion, our study demonstrates that TBRGE-180 features derived from TSPO-positive volumes, kinetic information from dynamic [18F]FET PET, kurtosis from T2 images, and age are important biomarkers for IDH prediction and even allow for an IDH mutation status prediction in glioma patients without ring enhancement on T1-weighted MRI. The gene discussed is IDH1; the disease is glioma.