Consistent with the in vitro observations a significant increase in levels of cleaved PARP and p-histone H2A.X(S189) were observed in vivo in PTEN null (HID28) tumours treated with a single dose of docetaxel on day 1 and with capivasertib on days 2–4 (Fig. 4f). This evidence concerns the gene PTEN and neoplasm.