Using TCGA and GTEx database gene expression profiles and survival information, 44 glycosylation regulators associated with overall glioma survival were identified, and risk prognostic models based on seven genes (BGN, C1GALT1C1L, GALNT13, SDC1, SERPINA1, SPTBN5, TUBA1C) were developed and validated using CGGA database data for external data validation (Fig. 11). The gene discussed is SPTBN5; the disease is central nervous system cancer.