Using TCGA and GTEx database gene expression profiles and survival information, 44 glycosylation regulators associated with overall glioma survival were identified, and risk prognostic models based on seven genes (BGN, C1GALT1C1L, GALNT13, SDC1, SERPINA1, SPTBN5, TUBA1C) were developed and validated using CGGA database data for external data validation (Fig. 11). This evidence concerns the gene C1GALT1C1L and central nervous system cancer.