Currently, studies on the prognosis of gliomas have also shown that annexin A2 (ANXA2) is an unfavorable factor in the prognosis of gliomas, whereas annexin A2 is closely associated with glycosylation, so it is reasonable to believe that glycosylation and related genes play an important role in glioma development24. This evidence concerns the gene ANXA2 and central nervous system cancer.