In our study, DCE-MRI histogram parameters of quantitative perfusion indexes (Ktrans, Kep, Fp, Vp, Ve) were used to explore the value in differential diagnosis of pathological types of NSCLC, and to evaluate the correlation between microvascular parameters of NSCLC with EGFR gene mutation and EGFR, VEGF protein expression, so as to provide a non-invasive and repeatable imaging detection means for the detection of the microvascular status of NSCLC in vivo. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.