We further show that microglia nodules in MS compared to stroke have upregulated genes associated with production of cytokines, specifically IFNy and TNF (IRF8, GADD, IFNAR2, CD84, LRRK2, FADD, LPL, TLR2, EGR1, and IL18). This evidence concerns the gene LRRK2 and myeloid sarcoma.