Microglia nodules compared to non-nodular NAWM in MS had a significantly higher expression of a multitude of genes previously associated with MS pathology (CXCL16, IL18, MX1, LPL, CD14, CD83, IL1B, CDKN1A, GPNMB, HLA-DRB5, C1QA, C1qB, SPP1, TLR6, CHI3L1, after correction CXCL16, IL18, C1QA, C1qB remained significant)1,10,27,28,31–37. This evidence concerns the gene CHI3L1 and myeloid sarcoma.