Accordingly, we employed an IMQ-induced psoriasis-like mouse model36, where BALB/c mice were treated with IMQ cream on their shaved back skin for seven consecutive days, followed by intraperitoneal injection of 17A-Lytaca, control-Lytaca (co-assembly prepared from peptide fm-nbp that does not bind to IL-17A, Supplementary Fig. 11), methotrexate (MTX), fm-17Abp alone, fm-SRAL alone, or saline as control (Fig. 4a). This evidence concerns the gene IL17A and psoriasis.