In this study, we present a TPD approach that employs supramolecular co-assembly degraders derived from two peptide ligands with assembly-driven modification to selectively degrade interleukin-17A (IL-17A), a cytokine biomarker of autoimmune diseases with pro-inflammatory properties14, engaging class A scavenger receptor (SR-A). The gene discussed is IL17A; the disease is autoimmune disease.