HBD and COVID-19: For example, we identified markers of acute inflammation (ORM2) and hemolysis (HBA1, HBB, HBD, and CA1) as well as the hemolytic anemia associated protein PRDX2 with significantly elevated levels in the COVID-19 convalescents compared to healthy controls (Figs. 3B and 4), consistent with what had been found in acute COVID-19 patients with high IL-6 levels and severely ill patients31 (Table 1).