For colitis mice, the percentages of fluorescence-positive cells among these inflammatory cells from the PD-L1-Fc/Oxi-αCD nanoparticles-treated group were significantly higher than those from the PD-L1-Fc-treated group (Supplementary Fig. 10A, –D) and PD-L1-Fc/PLGA nanoparticles-treated group (Supplementary Fig. 11A, –D). The gene discussed is CD274; the disease is colitis.