Based on the favorable biocompatibility, sensitive ROS-responsiveness and good safety of 4-phenylboronic acid pinacol ester-conjugated cyclodextrin biomaterials (Oxi-αCD)20, we developed a PD-L1-Fc-loaded nanotherapeutic for site-specific delivery of PD-L1-Fc to the inflamed colon in IBD. The gene discussed is CD274; the disease is inflammatory bowel disease.