These results suggest that PD-L1-Fc can inhibit the recruitment of innate immune cells into the colon during DSS-induced colitis and that the inhibitory effect of PD-L1-Fc/Oxi-αCD nanoparticles is stronger than that of free PD-L1-Fc and PD-L1-Fc/PLGA nanoparticles. Here, CD274 is linked to colitis.