CD274 and colitis: At 8 h after intraperitoneal injection of PD-L1-Fc/Oxi-αCD nanoparticles, confocal laser scanning microscopy (CLSM) images revealed that a large amount of FITC fluorescence signal was detected in the colonic mucosa of colitis mice, whereas an extremely weak fluorescence signal was detected in normal mice (Fig. 2J), suggesting that the inflamed environment was beneficial for delivering the PD-L1-Fc protein via PD-L1-Fc/Oxi-αCD nanoparticles.