In contrast, schizophrenia samples displayed an overload of GRM3-associated HPTMs favoring gene expression, including H3K4Me3, H3panAc, H3K27Ac, H4K5Ac, and/or H4K16Ac (+61–110%, p < 0.05), with no alterations in the repressive mark studied (Fig. 4C). The gene discussed is GRM3; the disease is schizophrenia.