For example, cg15910486 within the promotor/5’UTR of NR3C1 was reported to be hypermethylated in children who experienced early-life adverse events; cg23416081 and cg15929276 located within the 5’UTR region of FKBP5 have previously been shown to alter cortisol reactivity and behaviour in children; cg20813374 located in the promotor/5’UTR of FKBP5 is a known stress-related epigenetic signature previously associated with myocardial infarction and inflammation; and cg03546163 in the 5’UTR of FKBP5 was shown to be differentially methylated in the context of Cushing’s syndrome [24, 65, 66, 72]. Here, NR3C1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.