SIRT3 and glioblastoma: Furthermore, we detected that single inhibition of SIRT3 or combination with RSL3 treatment increased the MDA level while decreasing the GSH/GSSG ratio in tumor tissues, revealing that SIRT3 inhibition in combination with RSL3 treatment can attenuate GBM growth by inducing ferroptosis through a reduction in the GSH level in vivo (Fig. 5C,, D).