The most significantly upregulated genes in LPC samples were PC-associated genes (e.g., DLX1, HPN, and SIM220–22), and well known PC-associated oncogenes such as ERG, MYC, and KLK323 were similarly upregulated in LPC samples (Supplementary Fig. 1b), supporting the validity of our data and indicating that it is a representative RP patient cohort. This evidence concerns the gene HPN and pachyonychia congenita.