Recent studies on several members of the mouse Prame gene family, including Pramel1, Pramel19, Pramex1 [16, 19, 23, 24], suggested that these proteins serve as inhibitors, repressing the RA/RAR signaling during germ cell development in spermatogenesis—a molecular mechanism previously reported for the role of PRAME in cancer cells [25, 47, 48]. The gene discussed is PRAME; the disease is cancer.