Such findings reinforce the role of VAPB-PTPIP51 tethering in FTD/ALS; clearly, if only mutant TDP43 disrupted the VAPB-PTPIP51 tethers it would mean that disease seen in wild-type TDP43 mice could not involve damage to the tethers. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.