The enriched top 10 pathways in HES group included antigen processing and presentation (P < 0.05), renin-angiotensin system (P < 0.05), endocrine and other factor-regulated calcium reabsorption (P < 0.05), tryptophan metabolism (P < 0.05), cell adhesion molecules (CAMs, P < 0.05), complement and coagulation cascades (P < 0.05), inflammatory bowel disease (IBD, P < 0.05), malaria (P < 0.05), ECM-receptor interaction (P < 0.05), and protein digestion and absorption (0.05 < P < 0.1). The gene discussed is REN; the disease is malaria.