In the current study, upregulation of c-Maf, GATA3, IL-5, and IL-13 in the colonic mucosa of HES goats confirmed that the colonic inflammation in growing goats caused by HES was attributed to the TH2 cytokine pattern, which might be related to the TH2-mediated immune disorder. This evidence concerns the gene IL5 and hypereosinophilic syndrome.