First, overall analyzed the key differential genes, TRAV and c-Maf, that separately severing as an antigen receptor of CD4+/8+ T cells or the promoter of the TH2 cell maturation [53], were linked to upregulated antigen processing and presentation and inflammatory bowel disease (IBD) pathways in colonic mucosa of HES goats. This evidence concerns the gene CD4 and inflammatory bowel disease.