P4-67), and 6 differential bacterial functions (ko04215, ko04660, ko04664, ko05170, ko05210, and ko05323) were closely related to the expression of immune-related DEGs that includes TRAV, KIR3DL, and c-MAF for antigen presentation; c-MAF, GATA3, IL-5, and IL-13 for TH2-mediated inflammatory process; A1AT1 and C3 for complement and coagulation cascades, indicating that the TH2-mediated colonic inflammation of the HES goats could be attributed to these bacterial species and functions [53]. The gene discussed is GATA3; the disease is colitis.