Although the status of DRP-1 levels in post-mortem brains of patients having CHCHD2 mutations remained to be investigated, our observations in Drosophila and cell models of hCHCHD2-Thr61Ile suggest that mitochondrial fragmentation linked to elevated DRP-1 level likely contributes to the pathogenesis of CHCHD2-linked PD. Here, DNM1L is linked to Parkinson disease.