As α-synuclein accumulation and aggregation are pathological hallmarks of PD and had been observed in a number of PD models including the CHCHD2 knock-in mice model [63, 64], we investigated α-synuclein expression in the CHCHD2-Arg145Gln NPCs (Fig. 7G). This evidence concerns the gene CHCHD2 and Parkinson disease.