The findings were validated in vivo where immune deficient Rag2-/- γc-/- mice on a BALB/c background, inoculated with A673 tumor cells to form xenografts, were injected with a combination of PAPP-A-2G6 TCR transgenic T cells and CD8 + depleted peripheral blood mononuclear cells (PBMC), along with relevant controls [132]. This evidence concerns the gene CD8A and neoplasm.