Insulin may also promote tumor formation by upregulating acyl-coenzyme A: cholesterol acyltransferase-1, which mediates cell proliferation and metastatic effects on CRC cells [10], increasing vascular cell adhesion molecule-1 expression in tumor endothelial cells, which changes the homing of other immune cells to the tumor microenvironment [9]. Here, INS is linked to colorectal carcinoma.