Subtype II is mainly enriched to viral infection, protein ubiquitination Gram-negative bacteria, neutrophils, multiple immune-related terms(Fig. 2C) and viral infections, bacterial infections and immune pathways (Fig. 2D), such as Epstein-Barr virus infection, herpes simplex virus 1 infection, pathogenic Escherichia coli infection, Salmonella infection, epithelial cell signaling in Helicobacter pylori infection, and tumor necrosis factor signaling pathways. The gene discussed is TNF; the disease is escherichia coli infection.