The risk score formula was derived to calculate a risk score of each PAAD patient based on the expression level of those genes: Risk Score = (-0.0200)*ENTPD1 +(0.3771)*NT5E+(-0.5485)*ATG5+(0.2836)*PIK3CA+(-0.3363)*IL10+(-0.1699)*TNF+(0.2760)*CASP1+(-0.0697)*P2RX7+(0.0660)*LY96+(0.0787)*MYD88+(-0.5336)*FOXP3+(0.9603)*IFNG+(0.2470)*IFNGR1. The gene discussed is PIK3CA; the disease is pancreatic adenocarcinoma.