Yang et al. [45] found that miR-200a activated HSCs by targeting the SIRT1/Notch1 signal pathway and the loss of miR-200a was correlated with Notch1 down-regulation in HSCs, indicating that deregulation of the miRNA-Notch axis could exert a pivotal function in liver fibrosis. Here, SIRT1 is linked to Hepatic fibrosis.