Moreover, the chloride channels CLCN3 and CLCN7 are known to participate in bone resorption because CLCN7 ablation leads to osteopetrosis in humans (Kornak et al, 2001) and CLCN3 contributes to organelle acidification in mice (Okamoto et al, 2008). Here, CLCN3 is linked to osteopetrosis.