BRAF and esophageal cancer: Extensive research has been conducted on BRAF mutations in various cancers, including melanoma, hairy cell leukemia, esophageal cancer, papillary thyroid carcinoma, and serous ovarian cancer.[8–13] Genetic disparities associated with BRAF mutations have been linked to specific clinical and pathological variables, such as smoking habits, gender, neoplastic histology, and clinical stage.[14,15]