AKT1 and pulmonary fibrosis: For example, inhibition of AKT/GSK3β/β-catenin signaling pathway down-regulated epithelial-mesenchymal transition to reduce lung fibrosis.[46] The TGF-β1/Smad signaling pathway was used to inhibit the epithelial-mesenchymal transition of renal tubules to improve renal interstitial fibrosis.[47] New research hotspots may be the frontiers of future exploration, with great potential for exploration and reference value.