Brain Natriuretic Peptide (BNP, also known as B-type natriuretic peptide) and cleaved inactive N- terminal fragment of the BNP precursor (N-terminal proBNP) are important biomarkers that can be used to evaluate patients with heart failure.[5] Secretion of BNP, which has an antagonistic effect against angiotensin II, increases during acute heart failure due to stress in the ventricles[6] and resists volume overload.[7]. This evidence concerns the gene NPPB and heart failure.